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Slow and gradual dose escalation also helps reduce gastrointestinal side effects and improve tolerability
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There was a significant 24% reduction in the composite primary outcome in the semaglutide group compared with those taking placebo, with first events occurring in 5.8 versus 7.5 people per 100 person-years of follow-up, such that 20 people would need to be treated for 3 years to prevent one primary event
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